Write a short note on the disorders/diseases of the thyroid gland.

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(N/A) The thyroid gland is located on either side of the trachea and consists of two lobes interconnected by a thin flap of connective tissue called the isthmus. It is composed of follicles and stromal tissues. The follicular cells synthesize two hormones: tetraiodothyronine or thyroxine $(T_4)$ and triiodothyronine $(T_3)$. Iodine is essential for the normal rate of hormone synthesis.
$1$. Hypothyroidism: Deficiency of iodine in our diet leads to hypothyroidism and enlargement of the thyroid gland,commonly called goitre. Symptoms include stunted growth (cretinism),mental retardation,low intelligence quotient,abnormal skin,and deaf-mutism. Hypothyroidism during pregnancy causes defective development and maturation of the growing baby. In adult women,it may cause irregular menstrual cycles.
$2$. Hyperthyroidism: This condition occurs due to cancer of the thyroid gland or the development of nodules,which increases the synthesis and secretion of thyroid hormones to abnormally high levels,adversely affecting body physiology.
$3$. Graves' Disease (Exophthalmic Goitre): This is a form of hyperthyroidism characterized by the enlargement of the thyroid gland,protrusion of the eyeballs,increased basal metabolic rate,and weight loss.

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$A$ is essential for the normal rate of hormone synthesis in the thyroid. Deficiency of iodine in our diet results in $B$ and enlargement of the thyroid gland,commonly called $C$. Select the correct combination for $A, B$,and $C$.

Graves' disease is caused by . . . . . . .

$A -$ Thyroid gland secretes a protein hormone called thyrocalcitonin $(TCT)$,which regulates the blood calcium levels.
$R - TCT$ is a hypercalcemic hormone.

When is thyrocalcitonin secreted?

What happens if iodine or thyroxine is added to water containing tadpoles?

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